近期发表论文： 1.Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome. Yan Y, Jiang W, Liu L, Wang X, Ding C, Tian Z*, Zhou R*. Cell. 2015 Jan 15;160(1-2):62-73. 2.ApoC3: an 'alarmin' triggering sterile inflammation. Gong T, Zhou R*. Nat Immunol. 2020 Jan;21(1):9-11. 3.Commensal viruses maintain intestinal intraepithelial lymphocytes via noncanonical RIG-I signaling. Liu L, Gong T, Tao W, Lin B, Li C, Zheng X, Zhu S*, Jiang W*, Zhou R*. Nat Immunol. 2019 Dec;20(12):1681-1691. 4.RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway. Wang X, Jiang W, Yan Y, Gong T, Han J, Tian Z*, Zhou R*. Nat Immunol. 2014 Dec;15(12):1126-33. 5.DAMP-sensing receptors in sterile inflammation and inflammatory diseases. Gong T, Liu L, Jiang W*, Zhou R*.Nat Rev Immunol. 2020 Feb;20(2):95-112. 6.Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Yan Y, Jiang W, Spinetti T, Tardivel A, Castillo R, Bourquin C, Guarda G, Tian Z*, Tschopp J, Zhou R*. Immunity. 2013 Jun 27;38(6):1154-63. 7.Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders. Jiang H, He H, Chen Y, Huang W, Cheng J, Ye J, Wang A, Tao J, Wang C, Liu Q, Jin T, Jiang W*, Deng X*, Zhou R*. J Exp Med. 2017 Nov 6;214(11):3219-3238. 8.TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity. Lang X, Tang T, Jin T, Ding C, Zhou R*, Jiang W*. J Exp Med. 2017 Feb;214(2):459-473. 9.Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes. Jiang W, Wang X, Zeng B, Liu L, Tardivel A, Wei H, Han J, MacDonald HR, Tschopp J, Tian Z*, Zhou R*. J Exp Med. 2013 Oct 21;210(11):2465-76. 10.GPCRs in NLRP3 Inflammasome Activation, Regulation, and Therapeutics. Tang T, Gong T, Jiang W*, Zhou R*. Trends Pharmacol Sci. 2018 Sep;39(9):798-811. 11.Control of Inflammasome Activation by Phosphorylation. Gong T, Jiang W*, Zhou R*. Trends Biochem Sci. 2018 Sep;43(9):685-699. 12.Orchestration of NLRP3 Inflammasome Activation by Ion Fluxes. Gong T, Yang Y, Jin T, Jiang W, Zhou R.Trends Immunol. 2018 May;39(5):393-406. 13.Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. He H, Jiang H, Chen Y, Ye J, Wang A, Wang C, Liu Q, Liang G, Deng X*, Jiang W*, Zhou R*.Nat Commun. 2018 Jun 29;9(1):2550. 14.CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation. Tang T, Lang X, Xu C, Wang X, Gong T, Yang Y, Cui J, Bai L, Wang J, Jiang W*, Zhou R*. Nat Commun. 2017 Aug 4;8(1):202. 15.The strategies of targeting the NLRP3 inflammasome to treat inflammatory diseases.Jiang H, Gong T, Zhou R*.Adv Immunol. 2020;145:55-93. 16.Tranilast directly targets NLRP3 to treat inflammasome-driven diseases.Huang Y, Jiang H, Chen Y, Wang X, Yang Y, Tao J, Deng X, Liang G, Zhang H, Jiang W*, Zhou R*.EMBO Mol Med. 2018 Apr;10(4). pii: e8689. 17.Plant Lectins Activate the NLRP3 Inflammasome To Promote Inflammatory Disorders.Gong T, Wang X, Yang Y, Yan Y, Yu C, Zhou R, Jiang W*.J Immunol. 2017 Mar 1;198(5):2082-2092. |
